baathist wavily: March 2013

Sunday, March 31, 2013

Texas district attorney and wife found dead

Kaufman County District Attorney Mike McLelland, and his wife Cynthia were found dead in their home Saturday. An assistant to Kaufman was also gunned down near his office two months ago.

By Nomaan Merchant,?Associated Press / March 31, 2013

Caution tape surrounds the home of Kaufman County District Attorney Mike McLelland and wife Cynthia McLelland who were found dead in their home near Forney, Texas, Saturday.

Ian C. Bates/The Dallas Morning News/AP

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A central Texas prosecutor and his wife were found killed in their house two months after one of his assistants was gunned down near their office, authorities said.

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Investigators found the bodies of Kaufman County District Attorney Mike McLelland and his wife, Cynthia, on Saturday, Kaufman County sheriff's Lt. Justin Lewis said. Police, FBI agents, Texas Rangers and deputies were part of the investigation.

Assistant District Attorney Mark Hasse was shot to death in a parking lot a block from his office on Jan. 31. No arrests have been made in his death.

Lewis declined to say how the couple died or whether authorities believe their deaths are linked to Hasse's. He wouldn't provide further details. Kaufman County is 33 miles southeast of Dallas.

Kaufman Police Chief Chris Aulbaugh told The Dallas Morning News that the McLellands had been shot in their home and although investigators didn't know if their deaths were related to Hasse's killing, they couldn't discount it.

"It is a shock," Aulbaugh told the newspaper. "It was a shock with Mark Hasse, and now you can just imagine the double shock and until we know what happened, I really can't confirm that it's related but you always have to assume until it's proven otherwise."

Sam Rosander, who lives in the same unincorporated area of Kaufman County as the McLellands, told The Associated Press on Saturday that sheriff's deputies were parked in the district attorney's driveway for about a month after Hasse was killed.

Aulbaugh said recently that the FBI was checking to see if Hasse's killing could be related to the March 19 killing of Colorado Department of Corrections head Tom Clements, who was gunned down after answering the doorbell at his home.

Evan Spencer Ebel, a former Colorado inmate and white supremacist who authorities believe killed Clements and a pizza deliveryman two days earlier, was killed in a March 21 shootout with Texas deputies about 100 miles from Kaufman.

Hasse was chief of the organized crime unit when he was an assistant prosecutor in Dallas County in the 1980s, and he handled similar cases in Kaufman County. After Hasse was killed, McLelland had said Hasse was one of 12 attorneys on his staff, all of whom handle hundreds of cases at a time.

"Anything anybody can think of, we're looking through," McLelland said after Hasse's death.

McLelland graduated from the University of Texas before a 23-year career in the Army, according to the website for the district attorney's office. He later earned his law degree from the Texas Wesleyan School of Law.

He and his wife have two daughters and three sons. One son is a police officer in Dallas.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/KPcde1qZFK0/Texas-district-attorney-and-wife-found-dead

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FCC confident in its mobile phone radiation limits, seeks second opinions

Cast your memory back to last summer. Sweep away memories of iPhone 5 leaks galore, and you might remember that the US Government Accountability Office (GAO) asked the FCC to reevaluate its radiation limits for mobile phones. Now a few seasons later, the FCC has finally wrapped up a report that responds to the GAO, and there are no changes to its RF radiation levels in sight because it feels comfortable with its current caps. "We continue to have confidence in the current exposure limits, and note that more recent international standards have a similar basis," reads the report. However, given that its guidelines were adopted in 1996, new research on radiation and the proliferation of mobile devices, the FCC would like some feedback regarding its restrictions. It's put out a call for comments from concerned parties and even federal health and safety bodies.

Though the freshly-released document didn't rock the proverbial boat, it made one change worth noting. The pinna (outer ear) is now classified an extremity, which means the FCC allows devices to hit the tissue with more radiation. Feel like poring through 201 pages of regulatory minutiae? Click the source link below for the commission's full dossier.

Filed under: Cellphones

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Via: The Verge

Source: FCC

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/wkfE4oWqOVk/

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Mike McLelland, Kaufman County District Attorney, Found Dead With Wife In Texas Home

KAUFMAN, Texas ? A sheriff's deputy says authorities are investigating the deaths of a North Texas county district attorney and his wife who were found dead in a home.

Kaufman County Sheriff's Office spokesman Lt. Justin Lewis said Saturday that the county District Attorney, Mike McLelland, and his wife, Cynthia, were found dead in a home in an unincorporated part of the county. Authorities have blocked off the street where the couple's last known address is located.

Lewis said he couldn't discuss the investigation in further detail, including how the couple died and whether investigators believe their deaths are linked to the Jan. 31 slaying of an assistant Kaufman County district attorney, Mark Hasse.

The Dallas Morning News reports that Kaufman Police Chief Chris Albaugh confirmed the couple was shot at their home.

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Source: http://www.huffingtonpost.com/2013/03/30/mike-mclelland-found-dead_n_2986663.html

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Is Sonianomics An 'Occult' Form Of Economics? - india news network

INDIA NEWS NETWORK: Is Sonianomics An ?Occult? Form Of Economics?

Is Sonianomics An ?Occult? Form Of Economics?

Instead of economics, are Congress president Sonia Gandhi?s pet welfare schemes drawn from the occult?

In an Indian Express column that evaluates 15 years of Sonia Gandhi?s leadership, Chairman of Oxus Investments Surjit S Bhalla says that the Congress chief?s economic policies, which were aimed at helping the poor, but ended up hurting them the most, defy ?pure reason? and dubs them ?occult economics?.

Her policies have their origin in the creation of the Congress in 1885 by the Theosophical Society, an occultist movement, he says.

?Sonia UPA?s alchemy raised procurement prices of food grains beyond reason, helped a few rich farmers (say 20 million) and massively hurt ten times as many landless agricultural workers. And by generating super-inflation for four years, transformed the Indian economy beyond recognition,? says Bhalla.

Bhalla also analyses the economics of MGNREGA, a UPA pet scheme aimed at giving employment to the rural poor.

According to Bhalla, as per the NSS data of 2009-10, of the Rs 1,70,000 crore spent on MGNREGA, only a fifth reached the intended beneficiaries. In other words, about Rs 1,40,000 crore went to the non-poor. The scheme has helped nothing but corruption, says Bhalla.

Another example of ?occult economics? is the 2013-14 budget, in which the government aims at 13 percent GDP growth and 16 percent expenditure growth, which is to be financed with a 19 percent growth in tax revenue.

A third example of this brand of economics is the Food Security Bill, which is slated to be presented in the current Budget session of Parliament. The bill seeks to provide subsidised food grains to 67 percent of the country?s population.

According to a recent report in The Hindu, the bill would burden the government with a subsidy bill of about Rs 1.35 lakh crore.

Such economic policies have already halved the GDP growth, doubled inflation, depreciated the rupee by 20 percent and widened the current account deficit to 6.7 percent of GDP.

For the country to come out of the economic rot, Sonia has to change her occult spots by resorting to economic reforms, the Bhalla says. Otherwise, the Congress?and with it the country?will perish.

Source: http://hyd-news.blogspot.com/2013/03/is-sonianomics-occult-form-of-economics.html

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Saturday, March 30, 2013

New Afghanistan Commander, Gen. Joseph Dunford: 'We're Here to Win'

In his first television interview since taking control of the international force in Afghanistan, Gen. Joseph Dunford told ABC News' Martha Raddatz that while he expects Afghanistan's insurgency to continue beyond the U.S. drawdown next year, he feels hopeful about the direction of the country.

"I'm very clear that we're here to win," said Dunford. "There are certain things that have to happen. We've got a complete security transition. ... We've got a complete political transition. I think successful elections in the spring of 2014 will be an extraordinary event in Afghanistan and really be a bellwether for the 10 years opportunity that will follow."

Dunford admitted that attacks on the force by Afghan colleagues, like the stabbing of 26-year-old Sgt. Michael C. Cable by a 10-year-old Afghan boy with whom he was working earlier this week, have "absolutely" had an impact on the force. Dunford called such "blue-on-green incidents" a significant threat.

"It's something I take very seriously as a commander, the lives of our young men and women," he said.

Last year, at least 62 coalition troops were killed by "insider attacks." As a result, Dunford said, the NATO coalition has increased training and counter-intelligence ability, including having armed men act as "guardian angels" present at meetings involving U.S. and coalition officials with their Afghan counterparts.

"This is not an area that we'll be complacent in, this is never an area where we'll say we've solved the insider threat problem," said Dunford. "Every day, we're focused on that, we take it serious and we put mitigation measures in place."

Similarly to his predecessor, Gen. John Allen, Dunford expressed cautious optimism about the future of Afghanistan after the withdrawal of U.S. combat troops next year. He said that the Afghan security forces have really taken the lead in protecting their country and are meeting all the benchmarks the Obama administration has set.

"When I look at the Afghan forces there are really three questions that I ask," he said. "One is: Can they assume the lead in 2013? ... And the answer is yes. The second question ... is: As I look to the elections of 2014, can they provide security? ... and the answer is yes. And the third question is: Can they affect full security transition at the end of 2014? And the answer is yes."

RELATED: Ex-US Afghanistan Commander Hopeful

The general maintained the biggest requirement for the Afghans' success will be a commitment by the U.S. and the international community to continue to support the country and its security forces. Just as The U.S. and its NATO allies have made clear to the rest of the world that the force will be drawing down in a year, the Taliban also knows, and it is poised to take advantage.

"We've seen some indication that the Taliban would like to be successful this year, particularly conducting high-profile attacks and assassinations of Afghan leaders to try to erode the will of the coalition, to try to address the confidence of the Afghan people," he told Raddatz.

The commander warned that a lack of confidence by the Afghan people in American and international support could be the greatest weapon for the extremists.

"Many people tell me they're more concerned about the uncertainty of the future than they are about the Taliban," said Dunford, adding that the Taliban "will attempt to feed those fears about the post-2014 environment."

Dunford said the U.S. does not expect that all violence will cease in Afghanistan by next year, but that the goal is to leave the country with a foundation for peace, and then follow up with advisory support.

"From my perspective, we'll still need to be in the four corners of the country post 2014," he said. "We'll still need to provide advice and assistance to the Afghan core level."

He said that, similarly to the situation in Iraq after the U.S. withdrawal, Afghanistan's ultimate success needs to be measured in years, not months.

"I see a great opportunity today for stability and security in Afghanistan 10 years from now," said Dunford. "But it is going to be a long-term process. ... What we are really trying to do by the end of 2014 is provide the Afghans with what I would describe as a 'decade of opportunity.' At that point, security and stability will be in their hands."

OptiTrack debuts $3,700 PRIME 17W mocap cam for small spaces

Independent creators keen on motion capture have had affordable solutions like cheaper sensors and Kinect-based implementations for awhile now, but a large space for moving around has usually been required. OptiTrack has come up with an answer to that problem, however, in the form of the PRIME 17W mocap camera that it introduced at the Game Developers Conference in San Francisco. The 1.7-megapixel lens has a 70-degree by 51-degree field of view that promises to capture motion in a relatively small space, which also means you need fewer cameras to get a full 360-degree shot. Other features include a global shutter, high-speed 360 FPS capture and low distortion, enabling UAV and sports tracking. At $3,700, it's still not exactly cheap, but it's certainly affordable enough for indie engineers and animators with space constraints to get started in the mocap biz.

Filed under: Cameras, Gaming

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Source: OptiTrack

Source: http://www.engadget.com/2013/03/29/optitrack-prime-17w/

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South Africa says Mandela makes progress, in good spirits

By Shafiek Tassiem

SOWETO, South Africa (Reuters) - South African former President Nelson Mandela is in good spirits and making progress, doctors said on Friday, after the 94-year-old anti-apartheid hero was taken to hospital for the third time in four months for a lung infection.

The medical report was a relief to South Africans who had been anxiously praying and waiting for an update on the health of the Nobel Peace Prize laureate, hospitalised before midnight on Wednesday. Global leaders sent their best wishes.

President Jacob Zuma's government had already reported Mandela was responding well to treatment, and Zuma had sought to reassure the nation, recalling that the revered statesman's advanced age meant he required frequent medical checks.

"President Nelson Mandela is in good spirits and enjoyed a full breakfast this morning," Zuma's office said in a statement.

"The doctors report that he is making steady progress. He remains under treatment and observation in hospital," it added.

Mandela became South Africa's first black president after winning the country's first all-race election in 1994.

A former lawyer, he is revered at home and abroad for leading the struggle against white minority rule - including spending 27 years in prison on Robben Island - and then promoting the cause of racial reconciliation.

In churches across South Africa, many included Mandela in their prayers on Good Friday, one of the most important days in the Christian calendar.

At the Regina Mundi Catholic Church in the Soweto township outside Johannesburg where Mandela once lived, churchgoers lit candles for him. "He's an icon today and we are free because of him," parishioner Oupa Radebe said.

"I hope this time God will have mercy on him to give him the strength and courage to continue to be an icon for our country," Father Benedict Mahlangu said at the service.

U.S. President Barak Obama sent Mandela his best wishes.

"When you think of a single individual that embodies the kind of leadership qualities that I think we all aspire to, the first name that comes up is Nelson Mandela. And so we wish him all the very best," he said.

"LIKE A FATHER"

Mandela's fragile health has been a concern for years as he has withdrawn from the public eye and mostly stayed at his affluent homes in Johannesburg and in Qunu, the rural village in the destitute Eastern Cape province near where he was born.

President Zuma has urged the nation to remain calm.

"Of course I have been saying to people, you should bear in mind Madiba is no longer that young and if he goes for check-ups every now and again, I don't think people must be alarmed about it," Zuma told the BBC on Thursday.

"In Zulu, when someone passes away who is very old, people say he or she has 'gone home'. I think those are some of the things we should be thinking about."

Madiba is the clan name by which many South Africans refer to Mandela, whose face adorns the country's new bank notes.

Despite his absence from the political scene for the past decade, he remains an enduring and beloved symbol of the struggle against racism.

"He's like a father to me ... There is no more apartheid, black and white can go to the same places," said Princess Nopuhle, a student, aged 18, in Johannesburg's Mandela Square.

As he has receded from public life, critics say his ruling African National Congress (ANC) has lost the moral compass he bequeathed it when he stepped down as president in 1999.

Under such leaders as Mandela, Walter Sisulu and Oliver Tambo, the ANC gained wide international respect when it battled white rule.

LEADER OF "GOLDEN PERIOD"

Once the yoke of apartheid was thrown off in 1994, it began governing South Africa in a blaze of goodwill from world leaders who viewed it as a beacon for a troubled continent and world.

Almost two decades later, this image has dimmed as ANC leaders have been accused of indulging in the spoils of office, squandering mineral resources and engaging in power struggles.

Mandela has been criticised for not doing enough to prevent an HIV/AIDS epidemic and for making political compromises in the transition from apartheid that led to the black majority being still largely excluded from the benefits of the country's mineral wealth.

But his achievement in leading South Africa out of apartheid and averting all-out racial war is seen as eclipsing this.

"Amongst most South Africans, he is associated with a so-called ?golden period' of the end of apartheid and the beginning of the new democratic state. He represents all of the best of that, including the reconciliation," said Nic Borain, an independent political analyst.

Mandela was in hospital briefly earlier this month for a check-up and spent nearly three weeks in hospital in December with a lung infection and after surgery to remove gallstones.

That was his longest stay in hospital since his release from prison in 1990 after serving almost three decades for conspiring to overthrow the apartheid government.

Mandela has a history of lung problems dating back to when he contracted tuberculosis as a political prisoner.

Many South Africans said they felt the country's problems had worsened since Mandela withdrew from active politics.

"There was more peace and freedom when he was running it. Now the splits have come back again," said Natascha Roberts, taking pictures of her family in front of a towering statue of Mandela at the Sandton City mall in suburban Johannesburg.

"If he can go on for another few years, it would be great."

Source: http://news.yahoo.com/africas-mandela-spends-second-night-hospital-091218340.html

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Friday, March 29, 2013

Who pays for roof seller or buyer? - Zillow Real Estate Advice

"roof in decent condition but needs to be replaced in a few years" is a pretty common inspection outcome.?? Our roof gave us 15 years after such an evaluation and replacement was not an emergency situation.

I'd probably get the insurance that insures the house and not the roof, and budget to replace the roof.?

If the new inspection says it needs to be replaced now, you may consider splitting the expense.? They don't owe you a brand new roof, just a functional roof with several years life span.

Source: http://www.zillow.com/advice-thread/Who-pays-for-roof-seller-or-buyer/485236/

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Fewer children mean longer life?

Thursday, March 28, 2013

New research into ageing processes, based on modern genetic techniques, confirms theoretical expectations about the correlation between reproduction and lifespan. Studies of birds reveal that those that have offspring later in life and have fewer broods live longer. And the decisive factor is telomeres, shows research from The University of Gothenburg, Sweden.

Telomeres are the protective caps at the end of chromosomes. The length of telomeres influences how long an individual lives.

Telomeres start off at a certain length, become shorter each time a cell divides, decline as the years pass by until the telomeres can no longer protect the chromosomes, and the cell dies. But the length of telomeres varies significantly among individuals of the same age. This is partly due to the length of the telomeres that has been inherited from the parents, and partly due to the amount of stress an individual is exposed to.

"This is important, not least for our own species, as we are all having to deal with increased stress," says Angela Pauliny, Researcher from the Department of Biological and Environmental Sciences at the University of Gothenburg.

Researchers have studied barnacle geese, which are long-lived birds, the oldest in the study being 22 years old. The results show that geese, compared to short-lived bird species, have a better ability to preserve the length of their telomeres. The explanation is probably that species with a longer lifespan invest more in maintaining bodily functions than, for example, reproduction.

"There is a clear correlation between reproduction and ageing in the animal world. Take elephants, which have a long lifespan but few offspring, while mice, for example, live for a short time but produce a lot of offspring each time they try," says Angela Pauliny.

The geese studied by researchers varied in age, from very young birds to extremely old ones. Each bird was measured twice, two years apart. One striking result was that the change in telomere length varied according to gender.

"The study revealed that telomeres were best-preserved in males. Among barnacle geese, the telomeres thus shorten more quickly in females, which in birds is the sex with two different gender chromosomes. Interestingly, it is the exactl opposite in humans," says Angela Pauliny.

###

The journal BMC Evolutionary Biology has classified the research article "Telomere dynamics in a long-lived bird, the barnacle goose" as "Highly Accessed".

Link to the article: http://www.biomedcentral.com/1471-2148/12/257

University of Gothenburg: http://www.gu.se/english

Thanks to University of Gothenburg for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 34 time(s).

Source: http://www.labspaces.net/127500/Fewer_children_mean_longer_life_

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Ashley Judd not running for Senate (cbsnews)

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Thursday, March 28, 2013

Chrome Web Store search overhaul puts top category results on one page

If you've frequently been sifting through the Chrome Web Store for content, you've probably been stymied once or twice by search results that didn't initially show the content type you were looking for. At least some of us shouldn't face that problem following a quiet update from Google. Searches now show the top hits for apps, extensions and themes on one page, and a click of a category header is all that's needed for more detail. Just fire up Chrome (or a Chromebook) to see the remade results page.

Filed under: Internet, Google

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Via: Joe Marini (Google+)

Source: Chrome Web Store

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/OoWWSdh_bsg/

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Jenelle Evans Drug Use: Caught on Tape?!?

Source: http://www.thehollywoodgossip.com/2013/03/jenelle-evans-drug-use-caught-on-tape/

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The Transistor Desktop

The Transistor Desktop Reader Raghken was so enamored with the teaser trailer for Supergiant Games' upcoming title, Transistor (you can read all about it over at Kotaku) that he built this week's featured desktop around it. Even if you're unfamiliar with the game, the wallpaper is gorgeous.

If you are familiar with the game (or familiar with Supergiant Games' previous hit game, Bastion, you'll want to keep an eye out for Transistor. It looks great. If you're not into video games, just appreciate the stylized cityscape wallpaper, and the way Raghken incorporated Rainmeter into it like it belongs there.

Here's how he did it, and what you'll need to make it your own:

The wallpaper, an HD screencap from the Transistor teaser trailer
The Julius Sans One font for the Rainmeter widgets and system text (the same font used in the trailer)
Rainmeter, a system tweaking and monitoring tool for Windows
The Simple Media theme for Rainmeter for the time and date display
The Elementary theme for Rainmeter for the weather
The Rainbow theme for the app launcher in the upper left
The Muziko theme for Rainmeter for the "Now Playing" display

With those themes and the right font, you should have no trouble making this desktop your own, or just tweaking it so it fits better with your workflow. If you do run into issues though, stop by the original thread in our #featured-desktop forum to ask your questions, or check out our guide to Rainmeter for tips.

Do you have a good-looking, functional desktop that you want to see featured here? Submit it?along with where you got the wallpaper, skins, and geeklets?to us for review. We have two different ways you can share it with us:

Linux, Mac, Windows, all are welcome. Whatever you choose to use, include a description of how you made your desktop when you send it in. Without that, we can't tell others how to make it for themselves so they can be featured too!

Original Post via #featured-desktop

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/Kj5EY66obkQ/the-transistor-desktop

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Unique mechanisms of antibiotic resistance identified

Mar. 26, 2013 ? As public health authorities across the globe grapple with the growing problem of antibiotic resistance, Tufts University School of Medicine microbiologists and colleagues have identified the unique resistance mechanisms of a clinical isolate of E. coli resistant to carbapenems. Carbapenems are a class of antibiotics used as a last resort for the treatment of disease-causing bacteria, including E. coli and Klebsiella pneumonia, which can cause serious illness and even death. Infections involving resistant strains fail to respond to antibiotic treatments, which can lead to prolonged illness and greater risk of death, as well as significant public health challenges due to increased transmission of infection.

The study, published in the April issue of Antimicrobial Agents and Chemotherapy, demonstrates the lengths to which bacteria will go to become resistant to antibiotics.

Resistance to carbapenems usually emerges through the acquisition of an enzyme, carbapenemase, which destroys the antibiotic intended to treat infection. Resistance may also block entry of the drug into the E-coli bacteria. The current research, led by corresponding author Stuart Levy, M.D., Professor of Molecular Biology & Microbiology and of Medicine and Director of the Center for Adaptation Genetics & Drug Resistance at Tufts University School of Medicine, sought to determine what made this particular clinical isolate of E. coli resistant to carbapenem in the absence of carbapenemase.

"The Centers for Disease Control and Prevention has documented a significant increase in Carbapenem-resistant Enterobacteriaceae (CRE) -- so-called 'super bugs' that have been found to fight off even the most potent treatments," Levy said. "We knew that bacteria could resist carbapenems, but we had never before seen E. coli adapt so extensively to defeat an antibiotic. Our research shows just how far bacteria will go with mutations in order to survive."

Levy and his colleagues determined that the E. coli genetically mutated four separate times in order to resist carbapenems. Specifically, the isolate removed two membrane proteins in order to prevent antibiotics from getting into the cell. The bacteria also carried a mutation of the regulatory protein marR, which controls how bacteria react in the presence of antibiotics. The isolate further achieved resistance by increasing expression of a multidrug efflux pump. Moreover, the researchers discovered that the E. coli was expressing a new protein, called yedS, which helped the drug enter the cell, but whose expression was curtailed by the marR mutation. yedS is a normally inactive protein acquired by some E. coli that affects how the drug enters the bacterial cell. It is generally expressed in bacteria through a mutation.

According to the Centers for Disease Control and Prevention, CRE germs have increased from 1% to 4% in the United States over the last decade. Forty-two states report having identified at least one patient with one type of CRE. Approximately 18% of long-term acute care hospitals in the United States and 4% of short-stay hospitals reported at least one CRE infection in the first half of 2012.

The clinical isolate of E. coli studied by Levy and his colleagues came from the sputum of a patient at Peking Union Medical College Hospital in Beijing, China, where three of the study authors are on the faculty. Drug resistance is a particularly serious public health concern in China, antibiotics are overprescribed and used widely in the livestock and farming industries.

"The first quinolone-resistant strains of bacteria came out of China, where we see that the drugs of last resort begin being used, because the other drugs don't work after so much overuse," Levy said.

Additional authors of the paper are Doug Warner, Director of Undergraduate Laboratories, Boston College; Qiwen Yang, Section Director of Clinical Microbiology, Department of Clinical Laboratory, Peking Union Medical College Hospital; Valerie Duval, Research Assistant at Tufts University Center for Adaptation Genetics and Drug Resistance; Minjun Chen, Professor of Clinical Microbiology, Peking Union Medical College Hospital; and Yingchun Xu, Chair, Department of Laboratory Medicine, Peking Union Medical College Hospital.

Research reported in this publication was supported by the National Institute of Allergies and Infectious Diseases of the National Institutes of Health under award number R01AI56021.

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The above story is reprinted from materials provided by Tufts University, via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Journal Reference:

D. M. Warner, Q. Yang, V. Duval, M. Chen, Y. Xu, S. B. Levy. Involvement of MarR and YedS in Carbapenem Resistance in a Clinical Isolate of Escherichia coli from China. Antimicrobial Agents and Chemotherapy, 2013; 57 (4): 1935 DOI: 10.1128/AAC.02445-12

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_environment/~3/9wv0dTUHF6I/130326112007.htm

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Wednesday, March 27, 2013

Kerry meets again with Afghan President Karzai

Secretary of State John Kerry walks to a meeting with Afghan President Hamid Karzai at the Presidential Palace in Kabul, Monday, March 25, 2013. Kerry embarked on talks Monday with Karzai amid concerns Karzai may be jeopardizing progress in the war against extremism with his anti-American rhetoric. The session came shortly after the U.S. military ceded control of its last detention facility in Afghanistan, ending a longstanding irritant in relations. (AP Photo/Jason Reed, Pool)

Secretary of State John Kerry listens as Afghan President Hamid Karzai speaks during their joint news conference at the presidential palace in Kabul, Monday, March 25, 2013. Kerry and Karzai made a show of unity Monday, shortly after the U.S. military ceded control of its last detention facility in Afghanistan, ending a longstanding irritant in relations between the two countries. Kerry, in Afghanistan for an unannounced visit, said he and Karzai were "on the same page" when it comes to peace talks with the Taliban. (AP Photo/Jason Reed, Pool)

Secretary of State John Kerry gestures towards Afghan President Hamid Karzai during their joint news conference at the Presidential Palace in Kabul, Monday, March 25, 2013. Kerry and Karzai made a show of unity Monday, shortly after the U.S. military ceded control of its last detention facility in Afghanistan, ending a longstanding irritant in relations between the two countries. Kerry, in Afghanistan for an unannounced visit, said he and Karzai were "on the same page" when it comes to peace talks with the Taliban. (AP Photo/Jason Reed, Pool)

KABUL (AP) ? U.S. Secretary of State John Kerry met again Tuesday with Afghan President Hamid Karzai, a day after they put on a show of unity as they tried to end recent bickering over anti-American comments made by the Afghan leader.

Kerry was also holding a series of meetings Tuesday at the American Embassy in Kabul before wrapping up his short visit. He was meeting participants in a U.S.-backed women's entrepreneurship program as well as civic leaders playing a role in preparing for Afghanistan's 2014 elections.

Earlier Tuesday, eight suicide bombers attacked a police headquarters in the eastern city of Jalalabad, killing five officers and wounding four, police said. Taliban spokesman Zabiullah Mujahid claimed responsibility for the attacks.

Kerry arrived Monday in Kabul amid concerns that Karzai may be jeopardizing progress in the war against extremism with his rhetoric. Karzai infuriated U.S. officials earlier this month by accusing Washington of colluding with Taliban insurgents to keep Afghanistan weak even as the Obama administration pressed ahead with plans to hand off security responsibility to Afghan forces and end NATO's combat mission by the end of next year.

After a private meeting, Kerry said he had asked Karzai about the comments and was very satisfied with the president's explanation. He said the two countries were on the same page as international forces prepare to end combat operations in 2014.

At a joint news conference after his talks with Kerry, Karzai told reporters his comments in a nationally televised speech had been misinterpreted by the media. Kerry demurred on that point but said people sometimes say things in public that reflect ideas they have heard from others but don't necessarily agree with.

"I am confident the president (Karzai) does not believe the U.S. has any interest except to see the Taliban come to the table to make peace and that we are completely cooperative with the government of Afghanistan with respect to the protection of their efforts and their people," Kerry said.

For his part, Karzai said he had been trying to make the point in his speech that if the Taliban really wanted foreign troops out of Afghanistan they should stop killing people.

As Kerry flew to Kabul on Monday, the U.S. military ceded control of the Parwan detention facility near Bagram, a year after the two sides initially agreed on the transfer. Karzai had demanded control of Parwan as a matter of national sovereignty.

The long-running dispute over the center had thrown a pall over ongoing negotiations for a bilateral security agreement to govern the presence of U.S. forces in Afghanistan after 2014. Both Kerry and Karzai lauded the transfer of the facility.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-03-26-Afghanistan-Kerry/id-3e2ef5dbab584682a6889d75eebc3499

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Tuesday, March 26, 2013

Facebook Says VoIP Calling Will Be Added To Its Messenger iOS App In The U.K. Today

Facebook is slowly beefing up the capabilities of its Messenger app as it moves to combat the rise of free VoIP apps like Whatsapp, Viber and Line. Today it's taking another baby step by expanding VoIP calling to U.K. users of its iOS app, following its initial test of the feature in Canada in January, which was soon followed by a U.S. rollout.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/RYzrbTmGK5A/

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News in Brief: Highlights from the American Physical Society meeting

Highlights from the APS March Meeting, Baltimore, March 18-22, 2013

By Science News Staff

Web edition: March 25, 2013

Enlarge

Tunnel antics

Fire ants are excellent diggers, but excavating tunnels (shown in artificial lab soil) in their underground lairs is easier if the soil is a little wet, new experiments show.

Credit: Nick Gravish

Fire ants need damp soil
Despite its name, the fire ant isn?t afraid of a little water. In fact, the insects need just the right amount of moisture in soil to build superior nests, new experiments show.

Researchers from Georgia Tech in Atlanta filled 14.5-centimeter-deep aluminum tubes with an artificial soil made up of tiny glass beads and various amounts of moisture. The team then gave the stinging, invasive insects 20 hours to get their nest on. CT scans revealed that at about 10 percent moisture content ? a medium amount ? the ants (Solenopsis invicta) built tunnels twice as long as they did in parched soil. The researchers speculate that the dash of water makes the soil particles glom together in a manner that makes for easy digging.

??If you keep your backyard dry, they may leave and dig in your neighbor?s backyard,? said Daria Monaenkova, who presented the research on March 21 at the American Physical Society meeting. When the researchers tried varying the size of the soil particles, it didn?t influence nest construction: The fire ants chugged along fine with small or large grains, at least until the soil particles became as big as small worker ants. ? Rachel Ehrenberg

A tree stressed in the forest really does make a sound
Experiments that aim to explain the high-pitched screams emitted by thirsty trees have linked the distress calls to bubbles that form within the sap. But there may be more to the sounds than meets the ear.

When trees experience drought or really cold weather, they sometimes produce sounds. Most such noises are too high in frequency for the human ear to detect. But the sounds can reach 140 decibels, as loud as a jet-engine level rumble, Alexandre Ponomarenko of Grenoble University in France explained March 21.

To get at what produces the noises, Ponomarenko and his colleagues took sections of larch and pine, sandwiched them inside a porous gel and applied pressure. Along with about half of the noises came bubbles within the plant cells, microscope images reveal. The researchers speculate that the remaining noises might come from the bubbles moving through other cells, or perhaps even the wood fracturing. ? Rachel Ehrenberg

Nanocrystals slither through tiny tubes
Nothing can squeeze through tight spaces quite like a nanocrystal. Physicists watched a small iron crystal slide through a tube with an opening less than half the diameter of the crystal itself. The finding could lead to remotely controlled nanomachines that navigate through confined quarters.

Using an electric field, the researchers drove an iron crystal 12 nanometers in diameter through a carbon nanotube like a train in a tunnel. The surprise came when the tube constricted to 5 nanometers in diameter: The iron nanocrystal altered its shape and squeezed through. Microscope images showed that the iron remained a crystalline solid.

?It was mind boggling to watch,? said Sinisa Coh, a physicist from the University of California, Berkeley, who presented the results March 21.

Coh and his team attribute the crystal?s dexterity to the collective movement of its atoms. The researchers think that only the surface atoms move ? the ones at the back of the crystal migrate along the tube?s edges to settle at the front, allowing them to conform to the size of the tube. ? Andrew Grant

Citations

Screaming trees: A. Ponomarenko, O. Vincent and P. Marmottant. Cavitation in trees monitored using simultaneously acoustics and optics. American Physical Society meeting, Baltimore, March 21, 2013. Abstract: [Go to]

Nanocrystals: S. Coh et al. Movement of solid iron nanocrystal through a constriction in the multiwall carbon nanotube. American Physical Society meeting, Baltimore, March 21, 2013. Abstract: [Go to]

Nanocrystals: S. Coh et al. Surface atom motion to move bulk crystals through constrictions. arXiv: 1302.5709. Posted February 22, 2013. [Go to]

Fire ants: D. Monaenkova. Effect of moisture content on nest construction activity of fire ants. American Physical Society meeting, Baltimore, March 21, 2013. Abstract: [Go to]

Suggested Reading

A. Yeager. Pop chirp bite crunch chew. Science News. Vol. 174, August 30, 2008, p. 26. Available online: [Go to]

R. Ehrenberg. Tiny tubes, big riddles. Science News. Vol. 178, December 4, 2010, p. 20. Available online: [Go to]

D. Strain Teamwork keeps fire ants high and dry. Science News. Vol. 179, May 21, 2011, p. 11. [Go to]

Source: http://www.sciencenews.org/view/generic/id/349200/title/News_in_Brief_Highlights_from_the_American_Physical_Society_meeting

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Spring snowstorm hits central states, pushes east

Korey Estes launches a snowball at his son, James Gordon, at the top of Art Hill in front of the St. Louis Art Museum on Sunday, March 24, 2013, in St. Louis. A storm dumped 7 to 9 inches of snow from eastern Kansas into central Missouri before tapering off this morning. (AP Photo/St. Louis Post-Dispatch, J.B. Forbes)

Bobby Jones of Bel-Ridge, Mo., near St.Louis, clears the parking lane in front of his North Hanley Road home with his lawn tractor on Sunday, March 24, 2013, as a new blanket of wintry weather hits the St. Louis region early in Spring. (AP Photo/St. Louis Post-Dispatch, Christian Gooden)

Daffodils hang under the weight of snow near the Missouri History Museum in Forest Park on Sunday, March 24, 2013, in St. Louis. A storm dumped 7 to 9 inches of snow from eastern Kansas into central Missouri before tapering off this morning. (AP Photo/St. Louis Post-Dispatch, J.B. Forbes)

Children sled down and climb back up a hill on Klem Avenue in Overland, Mo., near St. Louis in nearly zero visibility as a Spring snowfall blankets the region on Sunday, March 24, 2013. (AP Photo/St. Louis Post-Dispatch, Christian Gooden)

A man waits for help after becoming stuck in snow along West 6th Street in Lawrence, Kan., Sunday, March 24, 2013. Few signs of spring are being found in parts of the Midwest as a snowstorm brings heavy snow and high winds. (AP Photo/Orlin Wagner)

KANSAS CITY, Mo. (AP) ? A wide-ranging storm is burying thoughts of springtime weather across a number of Midwestern states under a blanket of snow and slush, leaving in its wake dashed Palm Sunday plans, dozens of canceled flights and treacherous roadways as it churns eastward.

The National Weather Service issued storm warnings and advisories for Sunday and Monday for as far east as Pennsylvania, and officials were blaming two deaths in separate crashes in Kansas and Missouri on snow-slicked roads.

The system was expected to move into Ohio, bringing between 5 to 9 inches, said Dan Hawblitzel, a weather service meteorologist in suburban Kansas City.

Slick roads were also being blamed for a series of crashes on Interstate 60 north of Indianapolis that sent two people to area hospitals with life-threatening injuries. The Indiana State Police reported late Sunday that two people in a 2012 Subaru were hurt when the driver lost control while coming upon the scene of a previous crash involving a semitrailer. The Subaru hit the tractor-trailer and ended up in a ditch, police said. Authorities said both driver and passenger had life-threatening injuries and were taken to area hospitals. An update on their conditions was not immediately available.

Earlier Sunday night, a jack-knifed semi and subsequent fuel leak required a hazardous materials response outside Indianapolis, officials said. The Fishers Department of Fire and Emergency Services said a tractor-trailer was southbound on Interstate 69 when its driver lost control. No one was injured.

The storm was expected to weaken as it moved into Pennsylvania late Sunday and into Monday, with totals ranging from 3 to 8 inches. Before it exits off the coast of New Jersey on Monday night, the storm could leave 2 to 4 inches in that state as well as Delaware, northern Maryland and southern New York.

"It's definitely a wide-hitting system," Hawblitzel said.

To the west, parts of Colorado and northwest Kansas spent Sunday digging out from 10 to 15 inches of snow that were dumped there Saturday. Southwestern Nebraska got up to 7 inches. Winds gusting at speeds of up to 45 mph created snow drifts of 2 to 3 feet in the three states, said Ryan Husted, a meteorologist with the National Weather Service in Goodland, Kan.

"We have pretty much cleared out. Sunny skies. It's starting to melt a little bit," Husted said Sunday. Transportation officials reopened several closed highways, including a stretch of Interstate 70 spanning from Denver to Colby, Kan.

The storm dumped 7 to 9 inches of snow from eastern Kansas into central Missouri before tapering off Sunday morning, said Hawblitzel.

Authorities on Sunday also released the names of two people killed in separate crashes. In northeast Kansas, Anthony J. Hinthorne, 40, of Topeka, was killed Saturday afternoon in a single-vehicle crash and rollover on the Kansas Turnpike as snow was falling in Shawnee County, the Kansas Highway Patrol said. Later that night, Joshua J. French, 24, of Naperville, Ill., was killed when he lost control of his vehicle on a wet stretch of Interstate 35 in eastern Missouri's Clay County.

In the central Missouri town of Columbia, TV station KOMU was briefly evacuated Sunday morning because of high winds and a heavy buildup of snow on the broadcast tower next to the building. And Missouri Gov. Jay Nixon announced he was cancelling a couple events planned for Monday because of the weather.

___

Associated Press reporters Thomas Peipert in Denver and Sandy Kozel in Washington contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-03-25-US-Spring-Storm/id-d5e9b19c752744f99de3a1cade37dcf1

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Monday, March 25, 2013

Rare Beatles Shea Stadium photos sell for $47K

Getty Images

Paul McCartney, Ringo Starr, John Lennon and George Harrison of The Beatles.

By Miriam Coleman, Rolling Stone

A rare set of photographs taken at the Beatles' 1965 concert at Shea Stadium have just sold at auction for ?30,680 (around $46,700).

The BBC reports that the pictures were snapped by an amateur photographer named Marc Weinstein, who used a fake press pass to get backstage at the Beatles' biggest show. The historic New York concert drew more 55,000 fans, but there was only one other photographer present ? and he ran out of film.

The Beatles' "Please Please Me" 50th anniversary

In a 2009 interview, Weinstein described how he bluffed his way backstage:

"(I) had my press pass that was a phony press pass I made up," he said. "When I walked in there and I walked up to the first police officer I saw and ... ?I said (puts on English accent), ?Excuse me, sir, I?m with the Beatles entourage and I got separated from the group. Can you help me to the stage, please?? And he looked at me and he said, ?Sure, follow me.? And I was stunned. (Laughs.) He ate the whole thing. He started, ?Hey, guys, move out of the way. This guy is with the group. I?m taking him out there.? And I just followed him."

Paul McCartney recorded new songs with Mark Ronson

The set of 61 black-and-white photos were put up for sale by Omega Auctions on Friday, the 50th anniversary of the release of the Beatles' first album, "Please Please Me." ?They fetched far more than the pre-sale estimate of ?15,000-?20,000. According to the auctioneer, the photographs were purchased by "a South American gentleman currently living in Washington (who) is a huge collector of Beatles memorabilia."

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Why Startups Are Beating Carriers (Or The Curious Case Of The Premium SMS Horoscope Service & The Lack Of Customer Consent)

Any startups out there seeking to build a business by setting out to confuse as many users as possible with overly complex pricing structures, while tricking those who can't afford the full-fat service into signing up for ridiculously over-priced rubbish and then making it really hard for them to opt out? If so you'll want to look to carriers for inspiration.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/4TcVAVzkiZY/

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Girl Meets World: Cory & Topanga's Wedding Rings Revealed!

Source: http://www.thehollywoodgossip.com/2013/03/girl-meets-world-cory-and-topanga-wedding-rings-revealed/

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Wednesday, March 13, 2013

No casualties in magnitude 5.6 quake in Russia's Kamchatka

* Argentine forward strikes twice in 4-0 victory * Barca through to last eight 4-2 on aggregate * Villa, Alba also on the scoresheet for Spaniards (Writes through with quotes, details) By Iain Rogers BARCELONA, March 12 (Reuters) - A fired-up Lionel Messi inspired Barcelona to a sensational Champions League comeback against AC Milan with two goals in a thrilling 4-0 home victory on Tuesday to help the Spaniards reach the quarter-finals. ...

Source: http://news.yahoo.com/no-casualties-magnitude-5-6-quake-russias-kamchatka-044421986.html

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Friday, March 8, 2013

Comet PANSTARRS rises to the occasion mid-March

Mar. 8, 2013 ? Comets visible to the naked eye are a rare delicacy in the celestial smorgasbord of objects in the nighttime sky. Scientists estimate that the opportunity to see one of these icy dirtballs advertising their cosmic presence so brilliantly they can be seen without the aid of a telescope or binoculars happens only once every five to 10 years. That said, there may be two naked-eye comets available for your viewing pleasure this year.

"You might have heard of a comet ISON, which may become a spectacular naked-eye comet later this fall," said Amy Mainzer, the principal investigator of NASA's NEOWISE mission at the Jet Propulsion Laboratory in Pasadena, Calif., and self-described cosmic icy dirtball fan. "But if you have the right conditions you don't have to wait for ISON. Within a few days, comet PANSTARRS will be making its appearance in the skies of the Northern Hemisphere just after twilight."

Discovered in June 2011, comet 2011 L4 (PANSTARRS) bears the name of the telescopic survey that discovered it -- the less than mellifluous sounding "Panoramic Survey Telescope and Rapid Response System" which sits atop the Haleakala volcano in Hawaii.

Since its discovery a year-and-a-half ago, observing comet PANSTARRS has been the exclusive dominion of comet aficionados in the Southern Hemisphere, but that is about to change. As the comet continues its well-understood and safe passage through the inner-solar system, its celestial splendor will be lost to those in the Southern Hemisphere, but found by those up north.

"There is a catch to viewing comet PANSTARRS," said Mainzer. "This one is not that bright and is going to be low on the western horizon, so you'll need a relatively unobstructed view to the southwest at twilight and, of course, some good comet-watching weather."

Well, there is one more issue -- the time of day, or night, to view it.

"Look too early and the sky will be too bright," said Rachel Stevenson, a NASA Postdoctoral Fellow at JPL. "Look too late, the comet will be too low and obstructed by the horizon. This comet has a relatively small window."

By March 8, comet PANSTARRS may be viewable for those with a totally unobstructed view of the western horizon for about 15 minutes after twilight. On March 10, it will make its closest approach to the sun about 28 million miles (45 million kilometers) away. As it continues its nightly trek across the sky, the comet may get lost in the sun's glare but should return and be visible to the naked eye by March 12. As time marches on in the month of March, the comet will begin to fade away slowly, becoming difficult to view (even with binoculars or small telescopes) by month's end. The comet will appear as a bright point of light with its diffuse tail pointing nearly straight up from the horizon like an exclamation point.

What, if any, attraction does seeing a relatively dim naked-eye comet with the naked eye hold for someone who works with them every day, with file after file of high-resolution imagery spilling out on her computer workstation?

"You bet I'm going to go look at it!" said Mainzer. "Comet PanSTARRS may be a little bit of a challenge to find without a pair of binoculars, but there is something intimately satisfying to see it with your own two eyes. If you have a good viewing spot and good weather, it will be like the Sword of Gryffindor, it should present itself to anyone who is worthy."

NASA detects, tracks and characterizes asteroids and comets passing relatively close to Earth using both ground- and space-based telescopes. The Near-Earth Object Observations Program, commonly called "Spaceguard," discovers these objects, characterizes a subset of them, and predicts their paths to determine if any could be potentially hazardous to our planet.

JPL manages the Near-Earth Object Program Office for NASA's Science Mission Directorate in Washington, DC. JPL is a division of the California Institute of Technology in Pasadena.

More information about asteroids and near-Earth objects is at: http://www.jpl.nasa.gov/asteroidwatch , and on Twitter: @asteroidwatch .

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The above story is reprinted from materials provided by NASA/Jet Propusion Laboratory.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/space_time/nasa/~3/UH1xoP_8SKI/130308082117.htm

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Suggesting a sexual aid to my partner - Empty Closets - A safe ...

Yeah this contains sex, so 18+ maybe? I don't know.

As I'm asexual, sex with my boyfriend is rare, and by sex I mean hands and mouths only - I'm a virgin and that's how it's going to stay. While he never expects sex and doesn't mind this at all, I do like to 'treat' him sometimes, as it is quite an intimate experience which I feel is nice to share from time to time. However, when my boyfriend tries to reciprocate that, we don't really get anywhere. I usually have to ask him to stop because, while he really wants to give me pleasure, I know nothing's going to come of it. This has never, ever been an issue. I never feel disappointed when this happens and I really don't mind; it's my boyfriend that gets upset when he finds he can't satisfy me.

Before I was circumcised a few years ago, I had no problem with feelings during sexy times, despite being asexual. I lost these feelings after the operation. As a joke, a friend bought me some lube for a birthday. While bored, I gave it a go anyway, and it was great! I never tried it afterwards because I've never really felt like it, but just recently it got me thinking. If I were to get some, my boyfriend would be able to give me this satisfaction like he's always wanted to.

Here's my issue: because of the non-sexual relationship I have with my partner, I feel very odd and uncomfortable even thinking about speaking to him about this kind of thing. I would feel almost selfish bringing it up, and I know he's not really interested enough in sex to spend money on it. I feel that the relationship we have is just too good to be spoiled by bringing sex any further into it, yet I sort of yearn to be able to be part of what does happen.

I'm worried that mentioning this, or saying it the wrong way, could slightly change our relationship, or that I might come across as selfish or something. So should I bother? What should I say, and how should I say it? I know this seems quite trivial, but with such a perfect relationship, I need to make sure I do this right.

__________________
The only universally acknowledged truth is that Tom Nook is a dick.

Source: http://emptyclosets.com/forum/family-friends-relationships/86922-suggesting-sexual-aid-my-partner.html

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Early evidence shows 'good' cholesterol could combat abdominal aortic aneurysm

Mar. 6, 2013 ? New research provides early evidence that 'good' cholesterol may possess anti-aneurysm forming properties. In laboratory-based investigations, scientists found that increased levels of high-density lipoproteins (HDL), the so-called good cholesterol, blocked the development of aneurysms -- dangerous 'ballooning' in the wall of a blood vessel -- in the body's largest artery, the aorta.

The researchers say their findings -- which are published in the American Heart Association scientific journal Atherosclerosis Thrombosis and Vascular Biology -- lay the foundations for further investigations into ways of raising HDL cholesterol as a possible therapeutic intervention for the condition.

Abdominal aortic aneurysms can rupture and kill without warning. They are responsible for 6,000 deaths in England and Wales each year. There are no therapeutic treatments for aneurysms. Patients are monitored until the aneurysm reaches what is considered to be a critical size where it is at significant risk of rupturing -- 5cm in diameter -- and then it is repaired by surgery.

The study, led by researchers from St George's, University of London, found that elevating the amount of HDL cholesterol in the abdominal area of the aortic artery in mice both reduced the size of aneurysms that had already grown and prevented abdominal aortic aneurysms from forming at all.

The researchers say that while more work is needed to understand the exact mechanism by which HDL cholesterol effects aneurysms, their investigations indicate that raising HDL cholesterol influences the activity of the aortic artery's cells, which are the building blocks of its structure and function.

They found that elevated levels of HDL had two key influences on the cells. Firstly, it altered the signals sent between cells, which, in turn, reduced the activity of a protein called ERK1/2 that is known for its cell growth properties. Secondly, it increased levels of HDL cholesterol induced programmed cell death, which is an essential part of the cell lifecycle that sees old cells replaced with new ones.

The study focused on mice models of the area of the aorta just above the kidney (the suprarenal region) and the region that is just below the kidney and most commonly associated with aneurysm formation in humans (the infrarenal region). The researchers hope that the effects seen in these specific areas of the aortic artery will help explain basic mechanisms of aneurysm formation.

Dr Cockerill says: "HDL cholesterol is made up of a complex family of heterogeneous particles that may vary in composition, size and function. Whilst we have shown that elevating the concentration of the so-called 'good-lipid' can modulate site-specific cellular responses and inhibit aneurysm formation, it is important to learn more about changes that occur on HDL complexity in addition to the effects in the artery's responses that influence aneurysm development."

The researchers say that, in principle, if raising HDLs can be induced using a drug, it could offer a preventative measure to reduce the chance of an aneurysm developing for individuals considered at high risk of aneurysms. It could also offer a treatment option for patients from early diagnosis that could negate the need for surgery. But they point out that much more research is need before this becomes a reality.

The next phase of the investigations, which the researchers hope to begin this year, will see the researchers conduct laboratory tests with families of drugs that can elevate HDLs and reproduce the observed effects on aneurysms.

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Story Source:

The above story is reprinted from materials provided by University of St George's London.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Journal Reference:

E. Torsney, G. Pirianov, N. Charolidi, A. Shoreim, D. Gaze, S. Petrova, K. Laing, T. Meisinger, W. Xiong, B. T. Baxter, G. W. Cockerill. Elevation of Plasma High-Density Lipoproteins Inhibits Development of Experimental Abdominal Aortic Aneurysms. Arteriosclerosis, Thrombosis, and Vascular Biology, 2012; 32 (11): 2678 DOI: 10.1161/ATVBAHA.112.00009

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/wyOwBJsRzZY/130306084157.htm

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