Monday, May 6, 2013

Thousands of leftists protest Hollande's 1st year

PARIS (AP) ? Tens of thousands of supporters of leftist parties marched through central Paris on Sunday to express disappointment with President Francois Hollande's first year in power, criticizing the leader for reneging on his promises to rein in the world of finance and enact economic stimulus.

Hollande, a Socialist, rose to the presidency last May, promising to spare France the austerity measures imposed elsewhere in Europe. And the French government has largely avoided the deep spending cuts, big tax hikes and the wide-ranging reforms of many of its neighbors.

Instead, it has nibbled around the edges of its deficit, cutting 10 billion euros ($13 billion) in spending and increasing taxes, largely on the rich, by 20 billion euros. That's relatively little for a country with 2 trillion euro economy of which 57 percent is government spending.

Still, France's economy has continued to deteriorate, with growth stagnating and unemployment rising above 10 percent.

Leftists who took the streets on Sunday ? largely from parties to the left of Hollande's mainstream Socialist Party ? rejected the notion that Hollande had spared France a worse fate.

"Salaries are frozen. They continue to reduce hiring in the public sector," said Brigitte Blang, a 64-year-old teacher from eastern France. "We're waiting for true leftist policies. There's money in the coffers!"

Blang was among tens of thousands of people from around the country who gathered around Paris' iconic Place de la Bastille, named for the prison stormed by French revolutionaries in 1789. They carried signs that said, "Down with austerity," ''Out with finance, humans first" and "OUSTerity ? finance should pay."

Paris police said 30,000 people showed up, although protest organizers said there were 180,000. After speeches, the crowd marched to another Paris square.

Several protesters acknowledged that they voted for Hollande a year ago ? either simply to ensure the incumbent Nicolas Sarkozy's defeat or because they had hope for his leadership.

Hollande's failure to keep the support of those on the far left protesting in Paris on Sunday while also angering the right ?who think his economic reforms and budget cuts haven't gone far enough ? has made him one the least popular presidents in modern French history. In a sign of how he is being squeezed from both sides, 15,000 people ? largely right-leaning ? gathered in another part of Paris on Sunday to protest the recent passage of a law legalizing gay marriage.

Hollande and his ministers have pleaded for more time to allow their policies to take hold.

On the one hand, France's reluctance to enact major budget cuts may seem prescient to some as many economists and politicians in Europe rethink the austerity programs demanded in exchange for bailouts. The effects of budget cuts and tax increases have been much more detrimental to growth than some expected, and the prolonged recession and high unemployment in many countries has begun to make those policies untenable.

But others note that France hasn't just shied away from budget cuts, it has also skimped on reforms. While Spain and Italy may be struggling more than France currently, both countries are also laying the groundwork for a strong, durable recovery, many economists say.

France, on the other hand, may be left behind when the rebound comes since it has only partially committed to labor market reforms. Many of its companies are still not competitive on the world stage, its government spending is still too high and Hollande's administration has only exacerbated the impression that France is a difficult place to do business. One of his ministers has had very public spats with Goodyear, ArcelorMittal and Yahoo in the past year.

Hollande has been trying to turn that reputation around, recently unveiling a raft of tax cuts for entrepreneurs. But that announcement is a good example of the bind he finds himself in: Those very tax cuts were held up as a call to arms for Sunday's protest. And many deplored what they see as a stranglehold on power exercised by big companies and banks.

"Our march ... is a protest against the coup d'etat of the world of finance that is happening throughout Europe," said Jean-Luc Melenchon, the head of a grouping of leftist political parties known as the Left Front.

Source: http://news.yahoo.com/thousands-leftists-protest-hollandes-1st-143602009.html

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Saturday, May 4, 2013

New target for personalized cancer therapy

May 2, 2013 ? A common cancer pathway causing tumor growth is now being targeted by a number of new cancer drugs and shows promising results. A team of researchers at Case Western Reserve University School of Medicine have developed a novel method to disrupt this growth signaling pathway, with findings that suggest a new treatment for breast, colon, melanoma and other cancers.

The research team has pinpointed the cancer abnormality to a mutation in a gene called PIK3CA that results in a mutant protein, which may be an early cancer switch. By disrupting the mutated signaling pathway, the Case Western Reserve team, led by John Wang, PhD, inhibited the growth of cancer cells, opening the possibility to new cancer therapies.

Their findings, "Gain of interaction with IRS1 by p110? helical domain mutants is crucial for their oncogenic functions," was published on May 2 in the journal Cancer Cell.

Cancer arises from a single cell, which has mutated in a small number of genes because of random errors in the DNA replication process. These mutations play key roles in carcinogenesis.

"This discovery has a broad impact on the treatment of human cancer patients because so many cancers are affected by this particular mutation in the p110? protein, which is encoded by the PIK3CA gene," said Wang, an associate professor in the Department of Genetics and Case Comprehensive Cancer Center. "This is a significant advance because we can now disrupt this misdirected signaling pathway in cancer cells."

"If you turn on a light, you have to turn on a switch. But in the case of the mutation of this protein, p110? turns on by itself," Wang said. "The mutation rewires the circuit and is uncontrolled. This implies that if you break these wires, you can control the growth of cancer. Our current discovery may lead to finding less toxic drugs that can be used for personalized treatment for cancer patients in the future."

"This research will impact the field by focusing us on new targets for treating and preventing metastasis in patients in a many different types of human cancers," said Stanton Gerson, MD, Asa and Patricia Shiverick-Jane Shiverick (Tripp) Professor of Hematological Oncology, and director of Case Comprehensive Cancer Center and of Seidman Cancer Center at University Hospitals Case Medical Center.

Wang's multidisciplinary team of Case Western Reserve researchers includes: Yujun Hao, Chao Wang, Bo Cao, Brett M. Hirsch, Jing Song, Sanford D. Markowitz, Rob M. Ewing, David Sedwick, Lili Liu and Weiping Zheng.

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Story Source:

The above story is reprinted from materials provided by Case Western Reserve University, via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Yujun Hao, Chao Wang, Bo Cao, Brett?M. Hirsch, Jing Song, Sanford?D. Markowitz, Rob?M. Ewing, David Sedwick, Lili Liu, Weiping Zheng, Zhenghe Wang. Gain of Interaction with IRS1 by p110?-Helical Domain Mutants Is Crucial for Their Oncogenic Functions. Cancer Cell, 2013; DOI: 10.1016/j.ccr.2013.03.021

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/8Dcm91So1yo/130502185258.htm

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Heart cells change stem cell behavior

May 2, 2013 ? Stem cells drawn from amniotic fluid show promise for tissue engineering, but it's important to know what they can and cannot do. A new study by researchers at Rice University and Texas Children's Hospital has shown that these stem cells can communicate with mature heart cells and form electrical couplings with each other similar to those found in heart tissue. But these electrical connections alone do not prompt amniotic cells to become cardiac cells.

The study led by bioengineer Jeff Jacot, who has a joint appointment at Rice and Texas Children's, is part of ongoing research into repairing the hearts of infants born with congenital defects. Jacot's lab is designing scaffold patches that can be implanted into infant hearts. The patches, seeded with stem cells from the mother's own amniotic fluid, would ideally prompt the growth of healthy tissue that would not be rejected.

But to get there, researchers have to figure out how signals that are passed from cell to cell might guide stem cells to differentiate into heart tissue.

In a paper that appears today in the Journal of Cellular and Molecular Medicine, Jacot and his team found that amniotic fluid stem cells that are cultured with but physically separated from rat heart cells (to keep them from fusing) don't differentiate into heart cells. But the stem and heart cells do communicate through channels in the thin membrane that allow ions and small molecules to pass.

"People have suggested that if amniotic fluid cells are in an environment where they're near heart cells, something happens that causes differentiation of the amniotic fluid cells into cardiac tissue," Jacot said. "We found that isn't the case."

He said researchers have seen other types of stem cells take on the characteristics of cardiac cells and determined it was because the cells had fused together. "You get a single cell with proteins from both the stem cells and the heart cells," he said.

Jacot wanted to see if amniotic cells could take on the characteristics of heart cells if they weren't allowed to fuse. "We showed there's no evidence of actual cardiac differentiation, although there were some changes in protein expression (among the stem cells)," he said. But the stem cells "become electrically coupled to each other, like cardiac cells do with each other. That was the main finding: We do get very good electrical coupling, which we call functional gap junction connections.

"Electrical ions or really small molecules that are in one cell can diffuse directly into a cell next to it," he said. "It's like they put holes in their membranes when they're up against each other."

Knowing what signals are passed is of great value as researchers figure out how to prompt stem cells to differentiate into the desired tissue, Jacot said.

He said other labs are studying how injecting amniotic fluid stem cells directly into hearts can help recovery after a heart attack. "There are a lot of people doing this with bone marrow-derived stem cells in the U.S., including two of the biggest groups in Houston, the Methodist Hospital and the Texas Heart Institute," Jacot said. "They seem to find what we call paracrine signaling effects, where the stem cells draw in more blood vessel-forming cells. There's some discussion as to whether they stabilize the cells, but don't seem to actually make new heart tissue."

Jacot said there are probably many ways to get amniotic fluid stem cells to differentiate into viable tissue for medical uses, and the new results are just a small step toward the goal of finding the best way.

"What we've observed is a little removed from any kind of translational therapeutic aspect," he said. "But we feel what we've observed will help us understand amniotic fluid stem cells in this environment."

Co-authors are Rice graduate student Jennifer Petsche Connell, Rice junior Emily Augustini and maternal-fetal specialists Kenneth Moise Jr. and Anthony Johnson. Jacot is an assistant professor of bioengineering at Rice, director of the Pediatric Cardiac Bioengineering Laboratory at the Congenital Heart Surgery Service at Texas Children's and an adjunct assistant professor at Baylor College of Medicine.

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Story Source:

The above story is reprinted from materials provided by Rice University.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Jennifer Petsche Connell, Emily Augustini, Kenneth J. Moise, Anthony Johnson, Jeffrey G. Jacot. Formation of functional gap junctions in amniotic fluid-derived stem cells induced by transmembrane co-culture with neonatal rat cardiomyocytes. Journal of Cellular and Molecular Medicine, 2013; DOI: 10.1111/jcmm.12056

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/6cJLvFYjgWY/130502142700.htm

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Friday, May 3, 2013

Lindsay Lohan takes 270 outfits to 90-day rehab

Celebs

15 hours ago

It looks like Lindsay Lohan is planning to dress for success for her sixth stint in rehab. The troubled actress, who will start her court-mandated 90-day rehab sentence on Thursday at the Morningside Recovery Center in Newport Beach, Calif., won't be traveling lightly. On Tuesday night, she posted a photo on her Instagram account of herself surrounded by luggage and clothing, along with the caption "90 days and 270 looks."

Lohan's rehab wardrobe, which would give her three separate outfits per day, will be put to good use at the rehab facility, which boasts group activities such as bowling, sporting events and even supervised barbecues on the beach.

An abundance of clothing isn't the only thing that Lohan will be bringing to the rehab facility. The actress will also have a hefty supply of cigarettes. Morningside, unlike Lohan's first choice of rehab, the Seafield Center in New York, allows its residents to smoke in designated areas, prompting Lohan to change her rehab plans and fly west.

Lohan's latest rehab sentence comes after she pleaded no contest in March to charges of lying to a police officer and reckless driving from a June 2012 car crash. In addition to her mandatory stay in a locked rehab facility, the actress must also complete 30 days of community labor, pay fines and restitution to her victim, and attend psychological counseling sessions.

For her part, Lohan seems to be taking her rehab sentence in stride. In addition to posting the funny photo (which she later deleted from her Instagram account), Lohan told David Letterman last month that she is happy to be going to a treatment center.

"I don't think it's a bad thing," she told the late-night host in April. "I think it's a blessing...and not a curse."

Source: http://www.today.com/entertainment/lindsay-lohan-bring-lots-baggage-rehab-270-outfits-90-days-6C9723651

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If Medicaid is broken, who broke it? (Offthekuff)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories Stories, News Feeds and News via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/303007935?client_source=feed&format=rss

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PFT: Lacy says injuries won't hold him back

Marquise GoodwinAP

The Bills added a considerable amount of speed to their WR corps during the draft.

The Dolphins are holding a job fair today for their stadium project which may not happen.

A vote for T.J. Moe as the Patriots? unheard of rookie free agent who could make an impact.

Jets QB Greg McElory is fired up about the team adding former Alabama teammate Dee Milliner.

Ravens seventh-round WR Aaron Mellette has to make a big jump in competition, but they like his size and potential.

All the pressure?s on Bengals QB Andy Dalton, with the extra weapons he was given this offseason.

Free agent tackle Winston Justice decided to not take his tour to the Browns after all.

Steelers sixth-round LB Vince Williams has an opportunity for playing time.

As you?d expect, the Texans are expecting first-round WR DeAndre Hopkins to contribute immediately.

A number of Colts players said a gay teammate would not be a problem in their locker room.

Gene Frenette of the Florida Times-Union says the Jaguars can?t afford to give WR Justin Blackmon many more chances.

The Titans released two other guys Wednesday, in addition to WR Lavelle Hawkins.

Improvements in the run game could be just what the Broncos needed.

The Raiders brought back LS Nick Guess.

If free agent LT Bryant McKinnie signs with the Chargers, he?ll be the oldest man on the roster.

The Cowboys think third-round S J.J. Wilcox has a chance to start.

Former Giants OT Roman Oben worries that an entire generation of former players is destined to struggle with life after football, but that current players have a better chance.

New Eagles DT Bennie Logan was one of eight LSU defenders drafted this year, and one of eight children in his family growing up.

The Redskins have invited a number of players to minicamp on a tryout basis, including Penn State QB Matt McGloin.

The Bears are still in the process of shuffling their (large) scouting department.

The Lions added three more undrafted rookies to their previous class of eight.

The Packers hope that drafting RB Eddie Lacy will keep them from having to trust luck to find a running game.

New Vikings DE Lawrence Jackson took the same minimum-wage deal the Lions offered, saying it was a ?good fit.?

The Falcons signed undrafted rookie K Casey Barth, the younger brother of Buccaneers K Connor Barth.

Former Panthers coach John Fox was back in his old home (where he still has a home), playing the pro-am at the local PGA Tour Stop.

The Saints are giving former LSU K Josh Jasper a tryout.

Bucs undrafted rookie CB Deveron Carr has the kind of bonus that indicates competition for his services.

The Cardinals signed some CBs in free agency, but trading for Javier Arenas proves you can?t have too many.

The Rams loaded up in the secondary with their undrafted rookie class.

The 49ers are willing to roll the dice, and even signed an undrafted rookie from a Division II school who didn?t play last year.

The Seahawks are getting praise for their offseason moves.

Source: http://profootballtalk.nbcsports.com/2013/05/02/eddie-lacy-says-injuries-wont-hold-him-back/related/

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Thursday, May 2, 2013

Company IDs 7 killed in Afghanistan plane crash

DETROIT (AP) ? Jamie Brokaw was an experienced navigator who was no stranger to dangerous flying situations and had the skills to stay cool in the face of danger, according to close friend Chris Connerton.

"He was a very good person and very smart person," Connerton told The Associated Press by telephone from Rochester, Minn.

Brokaw, 33, of Monroe, Mich., was among seven Americans killed Monday when their National Air Cargo plane crashed near an Air Force base in Afghanistan. Six of the victims were from Michigan and a seventh was from Kentucky, said Shirley Kaufman, National Air Cargo vice president.

Connerton said Brokaw was a key reason he was able to make it through flight school in Jacksonville, Fla., where they met.

Connerton also described a harrowing flight two years ago from Toledo, Ohio, to an international flight expo in Lakeland, Fla. Connerton said ice had built up on the plane to the point that he could no longer get it to climb.

"If it wasn't for Jamie's navigation and know-how ... we wouldn't have made it," Connerton said.

Killed along with Brokaw in the Afghanistan crash were pilots Brad Hasler, 34, of Trenton, Mich., and Jeremy Lipka, 37, of Brooklyn, Mich.; first officer Rinku Summan, 32, of Canton, Mich.; loadmaster Michael Sheets, 36, of Ypsilanti, Mich.; and maintenance crewman Timothy Garrett, 51, of Louisville, Ky.

Building model planes and working on real ones comprised Stockdale's passion, filling the family's basement with models in his youth, jumping into aviation as a career at age 16 ? and later working at two Detroit-area airports.

Stockdale also knew the dangers of flying, his older brother said Tuesday.

"He always said it was dangerous," said Glenn Stockdale, 55. "He would always say, 'You either will die in a car crash or a ball of flame in a plane.'"

Lipka had flow in Iraq as well as Afghanistan and had close calls before, said his stepfather, Dave Buttman.

"There was risk there all the time. He knew the risks. He volunteered to take the trips," Buttman told the Star Tribune of Minneapolis. "Basically, you're taking your chances flying in there and he was just happy to be one of the pilots to do it."

The Dubai-bound Boeing 747-400 ? operated by National Air Cargo ? crashed just after takeoff Monday from Bagram Air Base around 11:20 a.m. local time, the National Transportation Safety Board said in a statement Tuesday.

The accident site is within the perimeter of Bagram Air Base.

The Taliban quickly claimed responsibility for downing the plane, but NATO said the claims were false and there was no sign of insurgent activity in the area at the time of the crash.

The Afghanistan Ministry of Transportation and Commercial Aviation is leading the investigation. The NTSB is investigating the crash alongside the ministry. The team will be composed of three NTSB investigators, as well as representatives from the Federal Aviation Administration and Boeing, the NTSB said.

Kaufman said the plane ? owned by National Airlines, an Orlando, Fla.-based subsidiary of National Air Cargo ? was carrying vehicles and other cargo.

Elena Garrett, of Jeffersonville, Ind., just across the Ohio River from Louisville, said ex-husband Timothy Garrett would have turned 52 on Saturday. They have two daughters together, ages 11 and 12.

"We're all devastated," Elena Garrett said about his death. "We were still best friends. He's the best father I've ever seen (and) ready to help anybody. He would give the shirt off his back for anybody."

Bill Hasler said his family learned Monday morning that his brother, Brad, was one of the crash victims.

"Brad was a wonderful father to two young children, a beloved husband to a wife who is expecting another child, a loving son, and the most loyal and supportive brother I could have ever asked for," Bill Hasler said in a statement. "His influence in the lives of all of us who loved him is immeasurable, and our grief is indescribable."

National Airlines was based until recently at Michigan's Willow Run Airport, west of Detroit. It carries cargo both commercially and for the military, Kaufman said. She said the company employs about 225 people.

Summan had worked 2? years for National Air Cargo, said his wife, Rajnit Summan.

Rajnit Summan said she last spoke to her husband Sunday.

"I told him to be safe," she said.

___

Joan Lowy reported from Washington. Associated Press writers David N. Goodman in Detroit and Elizabeth Campbell in Louisville, Ky., contributed to this report.

Source: http://news.yahoo.com/company-ids-7-killed-afghanistan-plane-crash-224039256.html

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